Nephron



  • Is urine hypotonic, hypertonic or isotonic relative to blood?

    The filtrate coming out of ascending loop of henle is hypotonic to blood. Does DCT make it hypertonic or isotonic? Please explain.



  • @anag
    Urine is hypertonic to blood
    Once the filtrate passes through the thick ascending limb of Henle, it enters the distal convoluted tubule, which is a duct of the renal tubule located in the kidney's cortex that reabsorbs calcium, sodium, and chloride and regulates the pH of urine by secreting protons and absorbing bicarbonate.
    Reabsorption and Secretion in the Distal Convoluted Tubule. Approximately 80 percent of filtered water has been recovered by the time the dilute forming urine enters the DCT. ... Aldosterone increases the amount of Na+/K+ ATPase in the basal membrane of the DCT and collecting duct.



  • @sunitasaxena What is the effect of "Aldosterone increasing the amount of Na+/K+ ATPase in the basal membrane of the DCT and collecting duct"?

    1. Does aldosterone cause more water reabsorption in DCT (by increasing number of aquaporins) or

    2. cause more Na+ reabsorption? Please explain.



  • @anag
    Yes



  • @sunitasaxena which is correct btw 1 & 2? I couldn't understand.

    What is the effect of "Aldosterone increasing the amount of Na+/K+ ATPase in the basal membrane of the DCT and collecting duct"? Please explain.



  • @anag
    Aldosterone causes an increase in salt and water reabsorption into the bloodstream from the kidney thereby increasing the blood volume, restoring salt levels and blood press


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